ReproSil-Pur Basic C18-HD is a silica-based HPLC column with high-density octadecyl bonded chemistry on ultra-pure silica. The HD (high-density) bonding provides enhanced surface coverage, which reduces residual silanol interactions and ensures excellent peak symmetry, even for challenging basic analytes such as amines, alkaloids, and cationic pharmaceuticals.
The combination of strong hydrophobic retention and optimized surface treatment makes ReproSil-Pur Basic C18-HD highly robust and versatile, with improved reproducibility and extended column lifetime compared to conventional C18 phases.
ReproSil-Pur Basic C18-HD combines strong hydrophobic retention with high-density bonding – the dependable choice for laboratories analyzing basic and polar analytes with maximum reproducibility.
High-purity silica with high-density octadecyl (C18) bonded chemistry
Optimized for basic and polar compounds with reduced silanol activity
Strong hydrophobic retention with excellent peak symmetry
High reproducibility and extended column lifetime
Available particle sizes: 3 µm - 10 µm
Pharmaceutical analysis of basic drugs, alkaloids, and amines
Biochemical separations of hydrophobic and polar metabolites
Food and beverage testing of nitrogen-containing additives and contaminants
Environmental monitoring of cationic and polar organic pollutants
Method development requiring robust and high-density C18 selectivity
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 450 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 25 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil-Pur Basic-C18-HD, 3 µm | r13.b9h. |
| ReproSil-Pur Basic-C18-HD, 5 µm | r15.b9h. |
| ReproSil-Pur Basic-C18-HD, 10 µm | r10.b9h. |