ReproSil 100 C18-TDE is a high-performance reversed-phase HPLC column from Dr. Maisch HPLC GmbH, packed with ultra-pure, fully porous spherical silica bonded with trifunctionally attached octadecyl ligands and featuring high-density endcapping. This advanced bonding chemistry ensures maximum deactivation of residual silanol groups, resulting in excellent peak symmetry and reproducibility, particularly for basic and polar analytes. With its strong hydrophobic retention, high surface coverage, and robust phase stability, ReproSil 100 C18-TDE is well suited for pharmaceutical analysis, impurity profiling, and stability-indicating assays, delivering highly reliable performance in both gradient and isocratic separations.
ReproSil 100 C18-TDE from Dr. Maisch HPLC GmbH combines robust trifunctional bonding with superior endcapping – the ideal column for laboratories requiring high-performance reversed-phase chromatography of small molecules.
Trifunctional C18 bonding with high endcapping – USP L1
100 Å pore size optimized for small molecules
Excellent peak shape for basic and polar compounds
Strong hydrophobic retention with robust stability
Manufactured and QC-tested by Dr. Maisch HPLC GmbH
Available in 5 µm and 10 µm particle sizes
Pharmaceutical impurity profiling and QC
Analysis of basic drug substances and metabolites
Stability-indicating reversed-phase HPLC methods
Method development requiring high reproducibility
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 280 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 18 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil 100 C18-TDE, 5 µm | r15.9tde. |
| ReproSil 100 C18-TDE, 10 µm | r10.9tde. |