ReproSil 100 RP18-NE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on fully porous, high-purity silica with a 100 Å pore size and bonded with octadecyl ligands. This phase is non-endcapped (NE), leaving residual silanol groups accessible for secondary interactions. The result is enhanced polar and ion-exchange selectivity, particularly useful for the separation of basic, polar, or closely related analytes. It offers a distinct retention mechanism compared to standard endcapped C18 columns and is well suited for method development requiring increased interaction diversity.
This non-endcapped C18 phase from Dr. Maisch HPLC GmbH delivers reproducible performance and enhanced polar interaction – ideal for challenging reversed-phase separations involving ionizable or closely related compounds.
Octadecyl (C18) bonded reversed-phase phase – USP L1
Non-endcapped surface for increased silanol interaction
Fully porous silica with 100 Å pore size
Strong retention of polar and ionizable compounds
Manufactured and QC-tested by Dr. Maisch HPLC GmbH
Available in 10 µm, 15 µm, and 20 µm particle sizes
Basic drug substances, polar pharmaceuticals, and structural isomers
Selectivity screening in reversed-phase method development
Analytes prone to weak retention on standard C18 columns
LC workflows requiring orthogonal selectivity
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 280 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| Carbonload | 16 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil 100 RP18-NE, 10 µm | r10.960. |
| ReproSil 100 RP18-NE, 15 µm | r115.960. |
| ReproSil 100 RP18-NE, 20 µm | r120.960. |