Reprospher 100 C18-Aqua is a specially modified reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 100 Å pore size and bonded with octadecyl groups. The phase features a polar surface modification that ensures excellent wetting and stable retention under 100% aqueous mobile phase conditions. This makes the column ideal for retaining and separating polar, hydrophilic, and early-eluting analytes that would otherwise exhibit poor interaction on conventional C18 phases. The enhanced aqueous compatibility supports reliable performance in LC-MS, pharmaceutical, and bioanalytical workflows.
Reprospher 100 C18-Aqua from Dr. Maisch HPLC GmbH combines C18 retention strength with aqueous stability – ideal for polar analytes and reversed-phase methods using high water content.
C18 bonded phase with Aqua-compatible polar modification
Stable operation in 100% aqueous eluents without phase collapse
Fully porous, high-purity silica with 100 Å pore size
Improved retention of polar and hydrophilic analytes
Available from 1.7 µm to 30 µm particle sizes
Polar drug substances, metabolites, and hydrophilic small molecules
Aqueous reversed-phase separations in bioanalysis and LC-MS
Method development for early-eluting or weakly retained compounds
Pharmaceutical and life science workflows requiring water-rich conditions
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 12 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C18-Aqua, 1.7 µm | rs117.9aq. |
| Reprospher 100 C18-Aqua, 1.8 µm | rs118.9aq. |
| Reprospher 100 C18-Aqua, 2 µm | rs12.9aq. |
| Reprospher 100 C18-Aqua, 2.5 µm | rs125.9aq. |
| Reprospher 100 C18-Aqua, 3 µm | rs13.9aq. |
| Reprospher 100 C18-Aqua, 5 µm | rs15.9aq. |
| Reprospher 100 C18-Aqua, 10 µm | rs10.9aq. |
| Reprospher 100 C18-Aqua, 30 µm | rs130.9aq. |