Reprospher 100 C18-Aqua-DE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on fully porous, high-purity silica with a 100 Å pore size. This phase combines octadecyl bonding with a polar surface modification for 100% aqueous compatibility and an advanced deactivation (double endcapping) process that reduces residual silanol activity. The result is excellent peak shape, stable retention, and reliable performance for basic, polar, and hydrophilic compounds — even under water-rich conditions. It is ideal for LC-MS, bioanalytical, and pharmaceutical workflows requiring improved selectivity and reproducibility for early-eluting and ionizable analytes.
Reprospher 100 C18-Aqua-DE from Dr. Maisch HPLC GmbH delivers stable reversed-phase performance in aqueous environments – ideal for sensitive analytes requiring high peak symmetry and low silanol interaction.
C18 bonded phase with polar surface modification and double endcapping
100% aqueous-compatible without phase collapse
Enhanced peak shape for basic and polar analytes
Fully porous silica with 100 Å pore size
Available in 3 µm and 5 µm particle sizes
Basic drug substances, metabolites, and polar excipients
Aqueous reversed-phase separations in LC-MS and bioanalysis
Method development with suppressed silanol interaction
Retention of weakly retained or early-eluting compounds
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 12 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C18-Aqua-DE, 3 µm | rs13.9aqd. |
| Reprospher 100 C18-Aqua-DE, 5 µm | rs15.9aqd. |