Reprospher 100 C8-Aqua is a specially modified reversed-phase HPLC column from Dr. Maisch HPLC GmbH, designed to operate reliably under 100% aqueous mobile phase conditions. Built on high-purity, fully porous silica with a 100 Å pore size and bonded with C8 ligands plus a polar surface modifier, this column offers enhanced retention of polar compounds while maintaining classical reversed-phase selectivity. The modification improves wetting, eliminates phase collapse in water-rich eluents, and enables excellent peak shape for polar and moderately hydrophobic analytes — ideal for LC-MS and bioanalytical applications.
Reprospher 100 C8-Aqua from Dr. Maisch HPLC GmbH combines aqueous stability with balanced hydrophobicity – a versatile reversed-phase column for challenging polar analytes and 100% aqueous mobile phase compatibility.
Octyl (C8) bonded phase
Stable performance under 100% aqueous conditions
Fully porous silica with 100 Å pore size
Improved retention of polar compounds without ion-pairing
Available from 1.8 µm to 10 µm particle sizes
Reversed-phase separation of polar drugs and hydrophilic metabolites
LC-MS-compatible methods with water-rich mobile phases
Bioanalytical and pharmaceutical workflows
Method development for aqueous elution conditions
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Modes | |
| USP Codes | |
| Endcapping | Yes |
| Carbonload | 8 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C8-Aqua, 1.8 µm | rs118.8aq. |
| Reprospher 100 C8-Aqua, 2 µm | rs12.8aq. |
| Reprospher 100 C8-Aqua, 2.5 µm | rs125.8aq. |
| Reprospher 100 C8-Aqua, 3 µm | rs13.8aq. |
| Reprospher 100 C8-Aqua, 5 µm | rs15.8aq. |
| Reprospher 100 C8-Aqua, 10 µm | rs10.8aq. |