Reprospher 100 C8-Aqua-DE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, specifically engineered for optimal performance under 100% aqueous mobile phase conditions and enhanced peak shape for basic analytes. Built on high-purity, fully porous silica with a 100 Å pore size, this phase combines a C8 ligand with a polar surface modification and advanced endcapping to suppress residual silanol activity. The result is excellent retention and peak symmetry for polar and ionizable compounds, making Reprospher 100 C8-Aqua-DE ideal for bioanalytical, pharmaceutical, and LC-MS compatible methods.
Reprospher 100 C8-Aqua-DE from Dr. Maisch HPLC GmbH delivers superior reversed-phase performance under aqueous conditions – ideal for polar and basic compounds where retention, peak shape, and reproducibility are critical.
Octyl (C8) bonded phase with deactivated silanol groups
Fully porous silica with 100 Å pore size
Stable performance in 100% aqueous eluents without phase collapse
Enhanced peak shape for basic and tailing-prone compounds
Available in 3 µm and 5 µm particle sizes
Basic and polar drug substances in bioanalytical HPLC
LC-MS methods under water-rich mobile phase conditions
Method development for hydrophilic APIs and metabolites
Reversed-phase separations in pharmaceutical and life science research
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Modes | |
| USP Codes | |
| Endcapping | Yes |
| Carbonload | 8 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C8-Aqua-DE, 3 µm | rs13.8aqd. |
| Reprospher 100 C8-Aqua-DE, 5 µm | rs15.8aqd. |