Reprospher 100 CN-DE is a cyano-modified HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 100 Å pore size. The phase combines cyanopropyl bonding with an advanced endcapping to reduce silanol activity and improve peak shape — especially for basic and polar analytes. Offering moderate hydrophobicity and strong dipole interaction, this column supports both reversed-phase and normal-phase separations with enhanced stability and reproducibility. It is ideal for method development when orthogonal selectivity or controlled polar interactions are needed.
Reprospher 100 CN-DE from Dr. Maisch HPLC GmbH offers flexible chromatographic performance with enhanced peak shape – ideal for reversed- and normal-phase separations involving polar, ionizable, or structurally related compounds.
Cyano bonded phase with deactivated surface – USP L10
Dual-mode use: reversed-phase and normal-phase HPLC
Fully porous silica with 100 Å pore size
Reduced silanol activity for improved peak symmetry
Available in 1.7 µm, 1.8 µm, 5 µm, and 10 µm particle sizes
Polar drugs, isomers, and aromatic compounds
Method development requiring moderate retention and orthogonal selectivity
Normal-phase chromatography of neutral and polar analytes
LC workflows requiring reduced peak tailing for polar species
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 7 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 CN-DE, 1.7 µm | rs117.cde. |
| Reprospher 100 CN-DE, 1.8 µm | rs118.cde. |
| Reprospher 100 CN-DE, 5 µm | rs15.cde. |
| Reprospher 100 CN-DE, 10 µm | rs10.cde. |