Reprospher 100 Diol is a polar HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 100 Å pore size and bonded with diol functional groups. The diol modification provides a neutral, hydrophilic surface that supports both normal-phase chromatography and HILIC (hydrophilic interaction liquid chromatography) retention mechanisms. Its low reactivity and well-controlled surface activity enable reproducible retention of polar, ionizable, and structurally related compounds. With its strong affinity for polar compounds, Reprospher 100 Diol offers reliable separation of sugars, sugar alcohols, and hydrophilic pharmaceuticals.
Reprospher 100 Diol from Dr. Maisch HPLC GmbH offers versatile polar selectivity for HILIC and normal-phase chromatography – ideal for laboratories working with highly polar analytes and complex sample matrices.
Diol-bonded silica phase – USP L20 classification
Supports normal-phase and HILIC retention mechanisms
Fully porous, high-purity silica with 100 Å pore size
Low silanol activity and excellent compatibility with polar analytes
Available in 3 µm, 5 µm, and 10 µm particle sizes
Separation of carbohydrates, polyols, and sugar alcohols
Polar drug substances and excipients
Normal-phase chromatography of neutral and polar compounds
HILIC-based method development for LC-MS applications
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | Diol |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| Carbonload | 7 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 Diol, 3 µm | rs13.d0. |
| Reprospher 100 Diol, 5 µm | rs15.d0. |
| Reprospher 100 Diol, 10 µm | rs10.d0. |