Reprospher 100 PFP is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 100 Å pore size and bonded with pentafluorophenyl ligands. The electron-deficient aromatic ring of the PFP group enables multiple interaction mechanisms, including π–π, dipole–dipole, hydrogen bonding, and hydrophobic interactions. This results in enhanced selectivity for polar, halogenated, and aromatic compounds — especially when classical C18 or phenyl phases provide insufficient resolution. With its orthogonal retention profile and strong polar selectivity, Reprospher 100 PFP is ideal for method development, isomer separation, and LC-MS workflows.
Reprospher 100 PFP from Dr. Maisch HPLC GmbH delivers advanced aromatic and polar interaction capabilities – the ideal column for challenging separations beyond the scope of standard C18 chemistry.
Pentafluorophenyl (PFP) bonded reversed-phase phase – USP L43
Fully porous silica with 100 Å pore size
Multiple retention mechanisms: π–π, dipole, and hydrogen bonding
Excellent selectivity for polar, aromatic, and halogenated compounds
Available in 5 µm and 10 µm particle sizes
Structural isomers and halogenated compounds
Polar aromatic analytes and bioactive molecules
LC-MS-compatible method development
Reversed-phase separations requiring alternative selectivity
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | PFP |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 22 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 PFP, 5 µm | rs15.pfpe. |
| Reprospher 100 PFP, 10 µm | rs10.pfpe. |