Reprospher HILIC-ARG is an HILIC (Hydrophilic Interaction Liquid Chromatography) column from Dr. Maisch HPLC GmbH, packed with ultra-pure, fully porous spherical silica functionalized with arginine groups. This unique surface chemistry combines hydrophilic interaction retention with weak cation-exchange properties, making it particularly effective for the separation of polar, acidic, and zwitterionic analytes. The guanidinium functionality of arginine provides strong polar interactions and controlled ionic selectivity, enabling sharp peak shapes and reproducible retention in LC-MS compatible high-organic eluents. Reprospher HILIC-ARG is especially suited for metabolomics, bioanalysis, and polar pharmaceutical compounds.
Reprospher HILIC-ARG from Dr. Maisch HPLC GmbH delivers robust and versatile HILIC performance – the ideal solution for laboratories analyzing polar, zwitterionic, and acidic compounds with high sensitivity and reproducibility.
Arginine-modified HILIC phase with dual-mode selectivity
Retention of highly polar, acidic, and zwitterionic analytes
Fully porous, high-purity spherical silica for reproducibility
Compatible with acetonitrile-rich eluents for HILIC and LC-MS
Manufactured and QC-tested by Dr. Maisch HPLC GmbH
Available in 3 µm, 5 µm, and 10 µm particle sizes
Separation of polar metabolites and amino acids
Bioanalytical HILIC of zwitterionic and acidic drugs
LC-MS workflows in metabolomics and pharmaceutical analysis
Method development requiring enhanced polar selectivity
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | Arginin |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| Carbonload | 15 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher HILIC-ARG, 3 µm | rs13.ARG. |
| Reprospher HILIC-ARG, 5 µm | rs15.ARG. |