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Chiral Chromatography enables the precise separation of enantiomers and stereoisomers with exceptional selectivity and reproducibility — a key technique for pharmaceutical, biochemical, and fine chemical analysis.
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Gel Filtration Chromatography (GFC), also known as Size Exclusion Chromatography (SEC), gently and reproducibly separates molecules by size in solution for the characterization and purification of water-soluble polymers, proteins, and biopolymers.
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Gel Permeation Chromatography (GPC) separates macromolecules by size in organic solvents, providing a reliable and interaction-free method for determining molecular weight and distribution of synthetic polymers.
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Hydrophilic Interaction Liquid Chromatography (HILIC) efficiently separates polar and hydrophilic compounds, bridging the gap between reversed phase and normal phase chromatography with full LC-MS compatibility.
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Ion Exchange Chromatography (IEX) separates charged molecules via electrostatic interactions, providing high selectivity and robustness for proteins, peptides, nucleotides, and other ionic compounds.
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Ion Exclusion Chromatography (IEC) selectively separates organic acids, alcohols, and other weakly ionized compounds in aqueous systems by electrostatic exclusion, effectively distinguishing ionic from non-ionic species.
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Normal Phase Chromatography is a powerful liquid chromatography technique for separating polar compounds, offering excellent selectivity for positional, structural, and stereochemical isomers often unresolved by reversed phase methods.
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Reversed Phase Chromatography is the most widely used HPLC mode, delivering exceptional versatility, reproducibility, and resolution for separating compounds ranging from small molecules to complex biomolecules.
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Supercritical Fluid Chromatography (SFC) combines the efficiency of gas chromatography with liquid chromatography, enabling fast, high-resolution separations of chiral, nonpolar, and thermally sensitive compounds under mild conditions.
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Core–Shell silica particles feature a solid core and porous shell, providing high efficiency, faster separations, and reduced backpressure — the next generation of stationary phase technology for HPLC and UHPLC.
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Fully porous silica particles form the classical backbone of HPLC, offering high surface area, mechanical stability, and reproducible performance for analytical and preparative separations in all major chromatographic modes.
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Organosilica hybrid particles unite the mechanical strength of silica with the chemical stability of polymers, offering superior pH tolerance, durability, and long-term stability for modern chromatographic applications.
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Non-porous silica particles are solid spheres with smooth, high-purity surfaces, ideal for protein, peptide, and affinity separations that require rapid mass transfer, reproducibility, and surface-specific interactions.
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Polymer particles are versatile, chemically robust materials with tunable porosity and surface chemistry, ideal as stationary phases or functional supports for analytical and preparative chromatographic applications.
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C18-functionalized silica phases provide robust, versatile, and high-performance surfaces for reliable reversed-phase chromatographic separations.
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C8-functionalized silica phases deliver reliable, efficient, and versatile separations with balanced hydrophobic selectivity in reversed-phase chromatography.
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C4-functionalized silica phases offer balanced hydrophobic retention and high recovery, making them a dependable choice for precise separations of peptides and proteins.
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C2-functionalized silica phases deliver gentle hydrophobic selectivity and fast, reliable separations for highly polar or early-eluting analytes in reversed-phase chromatography.
C1
C1-functionalized silica phases deliver minimal hydrophobic selectivity and fast, precise separations for highly polar or weakly retained analytes in reversed-phase chromatography.
CN
CN-functionalized silica phases offer versatile polarity and reproducible performance for precise separations in both reversed-phase and normal-phase chromatography.
NH₂
NH₂-functionalized silica phases deliver versatile polar selectivity and robust performance for normal-phase, HILIC, and ion-exchange chromatographic separations.
Phenyl
Phenyl-functionalized silica phases provide reliable aromatic selectivity and balanced hydrophobic interactions for precise and reproducible reversed-phase separations.
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SAX-functionalized silica phases deliver robust anion-exchange selectivity and reliable performance for high-resolution separations of negatively charged analytes.
SCX
SCX-functionalized silica phases offer robust cation-exchange selectivity and reliable, high-resolution separations for positively charged molecules.
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Diol-functionalized silica phases deliver hydrophilic, interaction-minimized surfaces for reliable separations in SEC, normal-phase, and HILIC chromatography.
Si
Bare silica phases deliver strong polar selectivity, high efficiency, and reproducible performance for normal-phase, adsorption, and HILIC separations.
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Other Phases
Nucleosil
Nucleosil 500
Nucleosil 500 OH (Diol)
Nucleosil 500 OH (Diol)
Specifications
Form
Column
Guard
Particle Size
7 µm
Length
13 mm
20 mm
30 mm
33 mm
40 mm
50 mm
60 mm
75 mm
100 mm
125 mm
150 mm
200 mm
250 mm
300 mm
Length
5 mm
10 mm
20 mm
Inner Diameter
1 mm
2 mm
3 mm
4 mm
4.6 mm
8 mm
10 mm
16 mm
20 mm
25 mm
30 mm
40 mm
50 mm
70 mm
100 mm
Weight
1 g
3 g
10 g
1000 g
Article Number
Request Product
Particle Size
7 µm
Pore Size
500 Å
Surface Area
35 m²/g
Phase/Modification
Diol
Particle Type
Silica / Fully Porous
Separation Modes
HILIC
Normal Phase
USP Code
L20
Material Number
Phase
Material Number
Nucleosil 500 OH (Diol), 7 µm
n57.d0.
Nucleosil 500 CN
Nucleosil 500 Si
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