Equisil CPS-2

Cyano-Modified HPLC Column with Enhanced Surface Deactivation for Reproducible Separations

Equisil CPS-2 is a reversed-phase HPLC column , featuring a cyano-bonded stationary phase on fully porous, high-purity silica with enhanced surface deactivation. The CPS-2 bonding offers the classic dual-mode selectivity of cyano phases — combining moderate hydrophobic retention with polar interaction capabilities — while minimizing unwanted silanol effects for improved peak symmetry and reproducibility. Designed for reversed-phase and polar normal-phase applications, Equisil CPS-2 provides faster elution of analytes that are over-retained on C18 columns, and is well suited for method development involving polar, aromatic, or moderately basic compounds.

Equisil CPS-2 offers reliable CN selectivity with reduced secondary interactions – ideal for modern HPLC workflows requiring fast, polar-selective, and reproducible separations.

Key Features

  • Cyano phase with enhanced deactivation – USP L10

  • Balanced polarity for reversed-phase and normal-phase use

  • Improved peak shape for polar and weakly retained analytes

  • High-purity silica with excellent batch-to-batch consistency

Typical Applications

  • Separation of polar organics and aromatic isomers

  • Fast reversed-phase analysis of moderately polar compounds

  • Method development requiring orthogonal selectivity to C18

  • Normal-phase LC using non-aqueous eluents

Specifications

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Particle Size
  • 3 µm
Pore Size 120 Å
Surface Area 180 m²/g
Phase/Modification CN
Particle Type
Separation Modes
USP Code
Endcapping No
Carbonload 5 %
pH Range 2 to 8

Material Number

Phase Material Number
Equisil CPS-2, 3 µm e23.ce.
Equisil CPS Equisil MOS

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