Exsil 100 Nitrile HL is a high-load cyanopropyl-modified silica-based HPLC stationary phase based on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The “HL” (High Load) surface design features an increased ligand density compared to standard nitrile phases, resulting in enhanced retention strength and higher sample loading capacity.
The moderately polar nitrile (CN) functionality provides dual-mode chromatographic behavior, enabling operation in both reversed-phase and normal-phase HPLC. Compared to conventional CN phases, Exsil 100 Nitrile HL offers stronger and more stable retention, improved robustness, and enhanced selectivity for demanding separations involving higher analyte loads.
Controlled silica synthesis and optimized surface bonding ensure excellent batch-to-batch reproducibility, consistent selectivity, and reliable chromatographic performance in routine analysis as well as method development.
Exsil 100 Nitrile HL combines enhanced loadability with versatile dual-mode selectivity, making it an excellent choice for demanding small-molecule HPLC separations requiring higher capacity and robust performance.
• High-load cyanopropyl (nitrile, CN) modified silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Increased ligand density for higher sample loading capacity
• Moderately polar surface with enhanced retention strength
• Dual-mode operation in reversed-phase and normal-phase HPLC
• Improved robustness and reproducible retention behavior
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle size available in: 5 µm
• Reversed-phase HPLC of polar to moderately nonpolar compounds
• Normal-phase separations requiring increased retention and loadability
• High-load separations of pharmaceutical APIs and intermediates
• Selectivity optimization for challenging small-molecule separations
• Method development and routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code |
| Phase | Material Number |
|---|---|
| Exsil 100 Nitrile HL, 5 µm | 5136524. |