Exsil 100 Octyl is an octyl-modified silica-based HPLC stationary phase based on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The C8-bonded ligand provides moderate to strong hydrophobic interactions, offering a well-balanced alternative between short-chain phases and highly retentive C18 materials.
Compared to C18 phases, Exsil 100 Octyl delivers reduced retention strength while maintaining excellent chromatographic efficiency and peak shape. This makes the phase particularly suitable for compounds that exhibit excessive retention on C18 columns or require improved selectivity through moderated hydrophobic interactions.
Controlled silica synthesis and stable octyl bonding ensure reproducible retention, consistent selectivity, and robust chromatographic performance in both routine analysis and method development.
Exsil 100 Octyl offers controlled hydrophobic selectivity and reliable performance, making it a versatile reversed-phase option for small-molecule HPLC separations where balanced retention is required.
• Octyl (C8)-modified silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Moderate hydrophobicity for balanced reversed-phase retention
• Reduced retention compared to C18 with improved selectivity control
• Excellent peak shape and reproducible retention behavior
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of small and medium-sized organic molecules
• Separation of pharmaceutical APIs and synthetic intermediates
• Analysis of compounds with excessive retention on C18 phases
• Method development requiring balanced hydrophobic selectivity
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 5 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Exsil 100 Octyl, 3 µm | 5136513. |
| Exsil 100 Octyl, 5 µm | 5136526. |
| Exsil 100 Octyl, 10 µm | 5136542. |