Exsil 100 Octyl-AB is an octyl-modified silica-based HPLC stationary phase with an embedded amide functionality, built on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The combination of a C8 hydrophobic ligand and a polar amide group results in a balanced surface chemistry that provides both hydrophobic retention and additional polar interaction sites.
The embedded amide functionality improves peak shape and retention stability for polar and basic analytes by reducing undesired silanol interactions. Compared to conventional C8 phases, Exsil 100 Octyl-AB offers enhanced selectivity, improved peak symmetry, and greater robustness across a wide range of mobile phase conditions.
Controlled silica synthesis and stable surface modification ensure excellent batch-to-batch reproducibility, consistent selectivity, and reliable chromatographic performance in both routine analysis and method development.
Exsil 100 Octyl-AB combines moderated hydrophobic retention with enhanced polar selectivity, making it an effective reversed-phase solution for challenging small-molecule separations requiring improved peak shape and robustness.
• Octyl (C8)-modified silica with embedded amide functionality
• 100 Å pore size optimized for small and medium molecular weight analytes
• Balanced hydrophobic and polar retention mechanisms
• Improved peak shape for polar and basic compounds
• Reduced silanol interactions compared to conventional C8 phases
• Reproducible retention and stable selectivity
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 3 µm, 5 µm
• Reversed-phase HPLC of polar and basic small molecules
• Separation of pharmaceutical APIs and intermediates
• Analysis of compounds sensitive to silanol interactions
• Method development requiring improved peak symmetry
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Mode | |
| USP Code |
| Phase | Material Number |
|---|---|
| Exsil 100 Octyl-AB, 3 µm | 5136517. |
| Exsil 100 Octyl-AB, 5 µm | 5136533. |