Exsil 100 Octyl-B is an endcapped octyl-modified silica-based HPLC stationary phase built on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The C8-bonded ligand provides moderate hydrophobic retention, while the additional endcapping step effectively reduces residual silanol activity.
This surface design results in improved peak symmetry and reduced secondary interactions, particularly for basic and polar analytes. Compared to non-endcapped C8 phases, Exsil 100 Octyl-B offers enhanced robustness, more reproducible retention, and increased method reliability across a wide range of mobile phase compositions.
Controlled silica synthesis and stable surface modification ensure excellent batch-to-batch reproducibility and consistent chromatographic performance in routine analysis and method development.
Exsil 100 Octyl-B combines balanced hydrophobic selectivity with improved surface deactivation, making it a reliable reversed-phase option for small-molecule HPLC separations requiring robust and reproducible performance.
• Endcapped octyl (C8)-modified silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Moderate hydrophobicity for balanced reversed-phase retention
• Reduced silanol activity for improved peak shape
• Enhanced robustness and reproducible retention behavior
• Suitable for polar and basic compounds compared to non-endcapped C8 phases
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of pharmaceuticals and synthetic intermediates
• Separation of basic and polar small molecules
• Analysis of compounds sensitive to silanol interactions
• Method development requiring improved robustness and reproducibility
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Mode | |
| USP Code |
| Phase | Material Number |
|---|---|
| Exsil 100 Octyl-B, 3 µm | 5136516. |
| Exsil 100 Octyl-B, 5 µm | 5136532. |
| Exsil 100 Octyl-B, 10 µm | 5136547. |