Exsil 100 ODS-1 is a low-coverage octadecyl-modified (C18) silica-based HPLC stationary phase based on high-purity Exsil 100 silica with a nominal pore size of 100 Å. Compared to standard ODS phases, the reduced ligand density provides lower hydrophobic retention while maintaining the characteristic selectivity of C18 chemistry.
This controlled surface coverage enables improved retention tuning and enhanced selectivity for compounds that are overly retained on conventional high-coverage C18 phases. Exsil 100 ODS-1 is particularly useful for separations requiring shorter retention times, improved resolution of closely eluting compounds, or increased sensitivity to subtle hydrophobic differences.
Controlled silica synthesis and stable ODS-1 bonding ensure reproducible retention behavior, consistent selectivity, and reliable chromatographic performance in both routine analysis and method development.
Exsil 100 ODS-1 provides controlled C18 selectivity with reduced retention strength, making it an effective reversed-phase option for small-molecule HPLC separations requiring fine-tuned hydrophobic interactions.
• Low-coverage octadecyl (C18) modified silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Reduced hydrophobic retention compared to standard ODS phases
• Improved selectivity control for closely eluting compounds
• Good peak shape and reproducible retention behavior
• Stable surface chemistry with high batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of small and medium-sized organic molecules
• Separation of compounds with excessive retention on standard C18 phases
• Selectivity optimization in pharmaceutical method development
• Analysis of moderately hydrophobic APIs and intermediates
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Phase | Material Number |
|---|---|
| Exsil 100 ODS-1, 3 µm | 5136520. |
| Exsil 100 ODS-1, 5 µm | 5136531. |
| Exsil 100 ODS-1, 10 µm | 5136551. |