Exsil 100 ODS-AB is an octadecyl-modified (C18) silica-based HPLC stationary phase with an embedded amide functionality, based on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The combination of strong hydrophobic C18 retention and a polar embedded amide group provides a balanced surface chemistry with enhanced interaction control.
The embedded amide functionality effectively reduces undesired silanol interactions, leading to improved peak symmetry and more stable retention, particularly for polar and basic analytes. Compared to conventional ODS phases, Exsil 100 ODS-AB offers enhanced selectivity, improved robustness, and greater method reliability across a wide range of mobile phase conditions.
Controlled silica synthesis and stable surface modification ensure excellent batch-to-batch reproducibility, consistent selectivity, and reliable chromatographic performance in routine analysis and method development.
Exsil 100 ODS-AB combines strong C18 retention with enhanced surface deactivation, making it a robust reversed-phase solution for small-molecule HPLC separations requiring improved peak shape and reliable selectivity.
• Octadecyl (C18, ODS) modified silica with embedded amide functionality
• 100 Å pore size optimized for small and medium molecular weight analytes
• Strong reversed-phase retention combined with polar interaction control
• Improved peak shape for polar and basic compounds
• Reduced silanol activity compared to conventional ODS phases
• Stable and reproducible retention behavior
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of polar and basic small molecules
• Separation of pharmaceutical APIs and synthetic intermediates
• Analysis of compounds sensitive to silanol interactions
• Method development requiring improved peak symmetry and robustness
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code |
| Phase | Material Number |
|---|---|
| Exsil 100 ODS-AB, 3 µm | 5136519. |
| Exsil 100 ODS-AB, 5 µm | 5136536. |
| Exsil 100 ODS-AB, 10 µm | 5136550. |