Exsil 100 ODS-B is an endcapped octadecyl-modified (C18) silica-based HPLC stationary phase based on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The additional endcapping step effectively deactivates residual silanol groups, resulting in reduced secondary interactions and improved chromatographic robustness.
Compared to non-endcapped ODS phases, Exsil 100 ODS-B provides improved peak symmetry, enhanced retention stability, and greater method reliability, particularly for basic and polar analytes. The phase combines strong reversed-phase retention with controlled surface activity, making it suitable for a wide range of routine analytical and QC applications.
Controlled silica synthesis and stable surface modification ensure excellent batch-to-batch reproducibility and consistent chromatographic performance in both routine analysis and method development.
Exsil 100 ODS-B combines strong C18 retention with effective surface deactivation, making it a reliable and robust reversed-phase standard for small-molecule HPLC separations.
• Endcapped octadecyl (C18, ODS) modified silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Strong reversed-phase retention with reduced silanol activity
• Improved peak shape for basic and polar compounds
• Enhanced robustness and reproducible retention behavior
• Broad applicability as a general-purpose C18 phase
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of pharmaceutical APIs and intermediates
• Separation of basic and polar small molecules
• Routine QC and validated analytical methods
• Method development requiring robust and reproducible retention
• General-purpose reversed-phase separations in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code |
| Phase | Material Number |
|---|---|
| Exsil 100 ODS-B, 3 µm | 5136518. |
| Exsil 100 ODS-B, 5 µm | 5136535. |
| Exsil 100 ODS-B, 10 µm | 5136549. |