Exsil 100 Phenyl-HL is a phenyl-modified silica-based HPLC stationary phase with high ligand loading, based on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The phenyl bonded phase enables π–π interactions in addition to hydrophobic retention, while the high-load (HL) surface design provides increased retention strength and higher sample loading capacity.
Compared to standard phenyl phases, Exsil 100 Phenyl-HL offers enhanced selectivity and improved retention for aromatic and conjugated compounds. The increased ligand density results in more robust retention behavior, making the phase particularly suitable for demanding separations requiring higher loadability and stable selectivity.
Controlled silica synthesis and optimized surface modification ensure excellent batch-to-batch reproducibility, consistent chromatographic performance, and reliable behavior in both routine analysis and method development.
Exsil 100 Phenyl-HL combines enhanced aromatic selectivity with increased loadability and robust performance, making it a powerful reversed-phase option for challenging small-molecule HPLC separations.
• High-load phenyl-modified silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Enhanced π–π interaction selectivity for aromatic compounds
• Increased ligand density for higher sample loading capacity
• Strong and reproducible reversed-phase retention
• Improved robustness compared to standard phenyl phases
• High batch-to-batch reproducibility
• Suitable for analytical and preparative HPLC
• Particle sizes available in: 3 µm, 5 µm, 10 µm
• Reversed-phase HPLC of aromatic and conjugated compounds
• Separation of pharmaceutical APIs containing aromatic moieties
• Analysis of polycyclic and substituted aromatic compounds
• High-load separations requiring enhanced selectivity
• Method development and routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | Phenyl |
| Particle Type | |
| Separation Mode | |
| USP Code |
| Phase | Material Number |
|---|---|
| Exsil 100 Phenyl-HL, 3 µm | 5136521. |
| Exsil 100 Phenyl-HL, 5 µm | 5136537. |
| Exsil 100 Phenyl-HL, 10 µm | 5136552. |