Exsil 100 SCX is a strong cation-exchange (SCX) HPLC stationary phase based on high-purity Exsil 100 silica with a nominal pore size of 100 Å. The sulfonic acid functional groups provide a permanently charged surface, enabling strong and reproducible electrostatic interactions with positively charged analytes.
The strong cation-exchange surface chemistry makes Exsil 100 SCX particularly suitable for the separation of basic and cationic small molecules over a wide pH range. The phase delivers high retention strength, stable selectivity, and robust chromatographic performance, making it well suited for both routine analysis and method development in ion-exchange HPLC.
Controlled silica synthesis and robust surface modification ensure excellent batch-to-batch reproducibility, consistent chromatographic behavior, and reliable long-term performance.
Exsil 100 SCX provides strong and reproducible cation-exchange selectivity combined with robust performance, making it a reliable choice for ion-exchange HPLC separations of positively charged small molecules.
• Strong cation-exchange (SCX) silica-based HPLC phase
• 100 Å pore size optimized for small and medium molecular weight analytes
• Permanently charged sulfonic acid functional groups
• Strong and stable cation-exchange retention mechanism
• High selectivity for basic and positively charged compounds
• Reproducible retention behavior across a wide pH range
• High batch-to-batch reproducibility
• Suitable for analytical and preparative ion-exchange HPLC
• Particle sizes available in: 3 µm, 5 µm, 10 µm, 12 µm
• Ion-exchange HPLC of basic and cationic compounds
• Separation of amines and basic pharmaceutical APIs
• Analysis of ionic pharmaceutical intermediates
• Method development for strong cation-exchange separations
• Routine QC in pharmaceutical, chemical, and analytical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 200 m²/g |
| Phase/Modification | SCX |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| Phase | Material Number |
|---|---|
| Exsil 100 SCX, 3 µm | 6136831. |
| Exsil 100 SCX, 5 µm | 5136530. |
| Exsil 100 SCX, 10 µm | 5136546. |
| Exsil 100 SCX, 12 µm | 5136660. |