Exsil Avanti NH2 (2)

Non-Endcapped Amino Phase for Normal-Phase, HILIC and Ion-Exchange HPLC

Exsil Avanti NH2 (2) is a high-performance amino bonded silica stationary phase, designed for versatile applications in normal-phase chromatography, HILIC, and weak anion-exchange separations. This non-endcapped version preserves accessible silanol groups on the silica surface, enabling additional polar and ionic interactions that can enhance selectivity for specific compound classes.

The amino functionality introduces a polar, weakly basic surface that supports hydrogen bonding, dipole–dipole interactions, and electrostatic retention mechanisms. In normal-phase mode, Exsil Avanti NH2 (2) provides efficient adsorption-driven separations of polar compounds such as carbohydrates and organic acids. In HILIC applications, it offers stable retention of highly polar and hydrophilic analytes under aqueous-organic mobile phase conditions. Because the phase is not endcapped, residual silanol activity contributes to secondary interaction mechanisms, which can improve resolution for certain analytes — particularly acidic and multifunctional compounds. Built on the advanced Exsil Avanti high-purity spherical silica platform, the phase delivers excellent mechanical strength, consistent packing quality, and reproducible chromatographic performance under both HPLC and UHPLC conditions.

Exsil Avanti NH2 (2) combines amino-phase polarity with controlled surface activity — offering flexible selectivity, reliable performance, and reproducible separations for polar and hydrophilic analytes in modern chromatographic systems.