GromSil 300 Butyl-1 ST is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on fully porous, high-purity silica with a 300 Å pore size and bonded with butyl (C4) ligands. Its short alkyl chain delivers weak hydrophobic retention, enabling faster elution of large, lipophilic or strongly retained analytes such as peptides, protein fragments, and hydrophobic drug substances.
The wide-pore structure ensures optimal accessibility and efficient mass transfer for high-molecular-weight compounds. Standard endcapping (ST) reduces silanol activity, improving peak symmetry and reproducibility under acidic or neutral conditions.
With its wide-pore design and mild hydrophobicity, GromSil 300 Butyl-1 ST from Dr. Maisch HPLC GmbH is ideal for fast, high-resolution reversed-phase separations of large or strongly retained biomolecules.
Butyl (C4) bonded reversed-phase phase with standard endcapping – USP L26
Fully porous silica with 300 Å pore size for large and hydrophobic analytes
Weak hydrophobic interaction for fast elution and sharp peaks
Excellent column efficiency and robust performance
Available in 5 µm and 10 µm particle sizes
Large peptides, protein fragments, and lipophilic biomolecules
Reversed-phase LC-MS and UV detection of high-MW analytes
Fast separations with improved peak shape for basic compounds
Method development requiring reduced retention for strongly binding analytes
| Particle Sizes |
|
|---|---|
| Pore Size | 300 Å |
| Phase/Modification | C4 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| GromSil 300 Butyl-1 ST, 3 µm | GSBU10330. |
| GromSil 300 Butyl-1 ST, 5 µm | GSBU10530. |
| GromSil 300 Butyl-1 ST, 10 µm | GSBU11030. |