GromSil 300 Cyan-1 ST is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 300 Å pore size and bonded with cyanopropyl (CN) ligands. This phase offers reduced hydrophobic retention and enhanced dipole interactions, making it ideal for separating aromatic, polar, or structurally similar large molecules. The standard endcapping (ST) ensures consistent performance and reduced silanol activity.
Thanks to its wide-pore architecture, the column provides excellent accessibility and mass transfer for large biomolecules such as peptides, oligonucleotides, and glycosylated compounds.
Combining polar selectivity with wide-pore efficiency, GromSil 300 Cyan-1 ST from Dr. Maisch HPLC GmbH is ideal for reversed-phase separations of large, polar, or structurally challenging molecules.
Cyanopropyl (CN) bonded reversed-phase phase – USP L10 classification
Fully porous silica with 300 Å pore size for high-molecular-weight analytes
Polar selectivity with reduced hydrophobic interaction
Standard endcapping for improved peak shape and reproducibility
Available in 5 µm and 10 µm particle sizes
Peptides, polar biomolecules, and glycosylated analytes
Separation of isomers or structurally related compounds
Orthogonal method development to C18 and phenyl phases
LC-MS and UV detection of polar or π-rich substances
| Particle Sizes |
|
|---|---|
| Pore Size | 300 Å |
| Phase/Modification | CN |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| GromSil 300 Cyan-1 ST, 3 µm | GSCN10330. |
| GromSil 300 Cyan-1 ST, 5 µm | GSCN10530. |
| GromSil 300 Cyan-1 ST, 10 µm | GSCN11030. |