GromSil 300 Diol is a polar HPLC column from Dr. Maisch HPLC GmbH, based on fully porous, high-purity silica with a 300 Å pore size and bonded with diol (–CH₂OH–CH₂OH) functional groups. Designed for normal-phase and HILIC-like separations, this wide-pore phase enables efficient retention of large hydrophilic molecules such as glycopeptides, oligosaccharides, and polar biomolecules.
The diol-modified surface provides strong hydrogen-bonding and dipole-dipole interactions with reduced silanol activity, ensuring sharp peaks and excellent reproducibility in both aqueous-organic and non-aqueous systems.
With its polar selectivity and wide-pore accessibility, GromSil 300 Diol from Dr. Maisch HPLC GmbH is an excellent choice for laboratories analyzing large, hydrophilic compounds in bioanalytical, pharmaceutical, or glycomic workflows.
Diol-modified polar phase – comparable to USP L20
Fully porous silica with 300 Å pore size for large polar analytes
Strong retention of hydrophilic and hydroxyl-rich compounds
Suitable for HILIC and normal-phase chromatography
Available in 5 µm and 10 µm particle sizes
Glycopeptides, sugar alcohols, oligosaccharides, and polar biomolecules
HILIC-like separations with acetonitrile-rich mobile phases
Normal-phase LC in non-aqueous solvent systems
Method development for polar compounds with large molecular structure
| Particle Sizes |
|
|---|---|
| Pore Size | 300 Å |
| Phase/Modification | Diol |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| GromSil 300 Diol, 3 µm | GSOH10330. |
| GromSil 300 Diol, 5 µm | GSOH10530. |