GromSil 300 NP-1 is a normal-phase HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 300 Å pore size and an unmodified (bare) surface. This wide-pore material is particularly suited for the separation of large, polar, or structurally complex molecules through adsorption and silanol-based interactions.
Its large pore diameter provides excellent accessibility and mass transfer for high-molecular-weight analytes, such as glycopeptides, polar biomolecules, or functionalized polymers, especially under non-aqueous conditions.
With its wide-pore architecture and high surface activity, GromSil 300 NP-1 from Dr. Maisch HPLC GmbH is ideal for laboratories performing polarity-driven separations of structurally diverse and large polar compounds.
Unmodified bare silica phase – USP L3 classification
Fully porous silica with 300 Å pore size for large polar analytes
Strong polar interactions for normal-phase and adsorption chromatography
Stable performance with non-aqueous mobile phases
Available in 5 µm and 10 µm particle sizes
Normal-phase LC of large biomolecules, glycosylated compounds, and isomers
Separation of polar analytes under hexane, heptane, or ethyl acetate conditions
Orthogonal method development to reversed-phase and HILIC modes
Dry-loading and sample preparation for preparative LC
| Particle Size |
|
|---|---|
| Pore Size | 300 Å |
| Phase/Modification | Si |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| GromSil 300 NP-1, 5 µm | GSNP10530. |