Reprospher 120 SCX-C8 is a mixed-mode HPLC column that combines strong cation exchange (SCX) functionality with hydrophobic C8 retention on spherical silica (120 Å pore size). This dual interaction mechanism enables simultaneous separation of positively charged analytes and nonpolar compounds, providing broader selectivity than conventional single-mode columns. The phase allows flexible method optimization by adjusting mobile phase pH, ionic strength, or organic content. With its robust surface chemistry and spherical silica support, Reprospher 120 SCX-C8 ensures reproducibility, sharp peak shapes, and long column lifetimes, making it particularly valuable for complex pharmaceutical and biochemical analyses.
Reprospher 120 SCX-C8 provides strong cation exchange capacity combined with C8 hydrophobicity – the reliable mixed-mode choice for challenging HPLC separations.
Mixed-mode stationary phase: strong cation exchange (SCX) + hydrophobic C8
Spherical silica with 120 Å pore size for high efficiency
Dual interaction mechanisms for basic/positively charged and hydrophobic analytes
Robust bonding for high reproducibility and column stability
Suitable for analytical and method development applications
Manufactured and QC-tested by Dr. Maisch HPLC GmbH
Available in 10 µm
Separation of basic pharmaceuticals and their hydrophobic impurities
Analysis of peptides and biomolecules with cationic functional groups
Biochemical and pharmaceutical impurity profiling
Method development requiring both ionic and hydrophobic selectivity
| Particle Size |
|
|---|---|
| Pore Size | 120 Å |
| Phase/Modification | C8-SCX |
| Particle Type | |
| Separation Modes | |
| USP Codes | |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 120 SCX-C8, 10 µm | rs10.scx8. |