ReproSil Chiral-AMS is a silica-based HPLC stationary phase coated with tris-(S)-α-methylbenzyl carbamate amylose, specifically developed for enantioselective separations under normal-phase conditions. The chiral selector, derived from amylose and substituted with (S)-α-methylbenzyl carbamate groups, provides distinct stereochemical recognition based on multiple interaction mechanisms, including hydrogen bonding, dipole–dipole, and π–π interactions.
This unique chiral structure enables high enantioselectivity and complementary selectivity profiles compared to other amylose- or cellulose-based chiral phases. The high-purity, spherical silica support ensures excellent mechanical stability, reproducibility, and column lifetime, even under routine or demanding analytical conditions. ReproSil Chiral-AMS is particularly suited for the resolution of racemic mixtures in pharmaceutical, chemical, and biochemical research as well as in quality control laboratories.
ReproSil Chiral-AMS combines amylose-based chiral recognition with the unique selectivity of (S)-α-methylbenzyl carbamate substitution – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.
Attractive alternative to CHIRALPAK® AS-H (Daicel®).
For the use of our ReproSil Chiral-AMS columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(S)-α-methylbenzyl carbamate amylose
Designed for enantioselective separations in normal-phase chromatography
Unique stereochemical selectivity based on the (S)-α-methylbenzyl carbamate structure
Excellent mechanical and chemical stability for reliable long-term use
Suitable for analytical and preparative enantioseparations
Separation of racemic compounds in pharmaceutical and fine chemical analysis
Enantioselective determination of optically active intermediates and products
Method development in chiral HPLC under normal-phase conditions
Research and quality control of chiral substances in chemical and biochemical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(S)-α-methylbenzylcarbamat-Amylose |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-AMS, 3 µm | r63.ams. |
| ReproSil Chiral-AMS, 5 µm | r65.ams. |
| ReproSil Chiral-AMS, 10 µm | r60.ams. |