ReproSil Chiral-CA

Pirkle-Type Chiral Phase for Compounds Containing Carboxylic Groups

ReproSil Chiral-CA is a silica-based HPLC stationary phase of the Pirkle type, specifically developed for the enantioselective separation of compounds containing carboxylic acid functionalities. The chiral selector is covalently bound to high-purity spherical silica and designed to interact selectively with acidic analytes through a combination of hydrogen bonding, π–π interactions, dipole–dipole forces, and ionic interactions, enabling high-resolution separations of structurally related enantiomers.

The chiral recognition mechanism of ReproSil Chiral-CA is tailored to analytes bearing carboxyl groups near the stereogenic center, such as α-hydroxy acids, amino acids, and pharmaceutical intermediates. The phase forms defined donor–acceptor complexes with the target molecules, resulting in excellent enantioselectivity, sharp peak shapes, and reproducible retention behavior. With its covalently bonded chiral selector and robust silica matrix, the phase exhibits high mechanical stability and solvent compatibility, suitable for use in normal-phase, reversed-phase, or polar-organic chromatographic modes. ReproSil Chiral-CA is particularly suited for pharmaceutical, biochemical, and chemical laboratories that require reliable, efficient, and reproducible separations of acidic chiral compounds.

ReproSil Chiral-CA combines the selectivity of a Pirkle-type chiral selector with the stability of high-purity silica – the reliable choice for accurate and reproducible enantioselective separations of compounds containing carboxylic acid groups.