ReproSil Chiral-CM is a silica-based HPLC stationary phase coated with 3-(phenylcarbamate) cellulose, developed for enantioselective separations under normal-phase conditions. The cellulose derivative provides multiple interaction mechanisms – including hydrogen bonding, π–π stacking, and dipole–dipole interactions – that enable excellent chiral recognition and high resolution for a wide range of racemic compounds.
The phenylcarbamate functionalization gives the phase a well-balanced selectivity profile, making it suitable for compounds of varying polarity and structural complexity. Built on high-purity, mechanically stable spherical silica, ReproSil Chiral-CM ensures reproducible performance, robust retention behavior, and long column lifetime even under routine analytical conditions.
This chiral phase is particularly suited for pharmaceutical, chemical, and biochemical applications, offering reliable and reproducible separation of enantiomers in both method development and quality control.
ReproSil Chiral-CM combines cellulose-based chiral recognition with the versatile selectivity of phenylcarbamate functionality – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.
Attractive Alternative to CHIRALCEL® OC-H (Daicel®).
For the use of our ReproSil Chiral-CM columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with 3-(phenylcarbamate) cellulose
Designed for enantioselective separations in normal-phase chromatography
High chiral recognition through hydrogen bonding, π–π, and dipole–dipole interactions
Balanced selectivity for a broad range of chiral analytes
High mechanical and chemical stability for long operational lifetime
Suitable for analytical and preparative chiral separations
Enantioselective separation of chiral pharmaceuticals and intermediates
Resolution of racemic mixtures in fine chemical synthesis
Quality control and purity testing of optically active compounds
Method development for chiral HPLC in pharmaceutical and biochemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | 3-(Phenylcarbamat)-Cellulose |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-CM, 3 µm | r63.cm. |
| ReproSil Chiral-CM, 5 µm | r65.cm. |
| ReproSil Chiral-CM, 10 µm | r60.cm. |