ReproSil Chiral-D-PhenylGlycin is a silica-based HPLC stationary phase of the brush-type Pirkle design, modified with N-(3,5-dinitrobenzoyl)-D-phenylglycine as the chiral selector. This phase is specifically developed for the enantioselective separation of herbicides, pharmaceuticals, and other aromatic chiral compounds. Its well-defined molecular architecture allows precise chiral recognition through donor–acceptor complexation, hydrogen bonding, π–π interactions, and steric complementarity.
The D-phenylglycine moiety serves as the chiral recognition center, while the electron-withdrawing 3,5-dinitrobenzoyl group provides strong π–acceptor properties, enabling high-resolution separations of analytes containing electron-donating aromatic or heteroaromatic groups. This makes ReproSil Chiral-D-PhenylGlycin particularly effective for compounds such as phenoxyacetic acid herbicides, pharmaceutical intermediates, and other aromatic chiral molecules. The chiral selector is covalently bound to high-purity spherical silica, ensuring excellent mechanical stability, solvent resistance, and reproducible performance. The phase can be used under normal-phase, reversed-phase, or polar-organic conditions, offering flexibility for a wide range of enantioselective separations in analytical and preparative applications.
ReproSil Chiral-D-PhenylGlycin combines the strong π–acceptor capability of the N-(3,5-dinitrobenzoyl) group with the chiral recognition power of D-phenylglycine – the reliable choice for precise and reproducible enantioselective separations of herbicides, pharmaceuticals, and aromatic chiral compounds.
Attractive Alternative to Nucleosil Chiral-2 (Macherey-Nagel).
Silica-based brush-type chiral stationary phase with N-(3,5-dinitrobenzoyl)-D-phenylglycine
Developed for enantioselective separations of herbicides, pharmaceuticals, and aromatic chiral compounds
Strong enantioselectivity via donor–acceptor, hydrogen bonding, and π–π interactions
Covalently bonded chiral selector for high stability and reproducibility
Applicable in normal-phase, reversed-phase, and polar-organic chromatography
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of phenoxyacetic acid herbicides and related agrochemicals
Resolution of aromatic and heteroaromatic chiral pharmaceuticals and intermediates
Method development for compounds with π–electron-donating functional groups
Quality control and stereochemical purity testing in pharmaceutical and chemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | N-(3,5-Dinitrobenzoyl)-D-Phenylglycin |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 - 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-D-PhenylGlycin, 3 µm | r13.DPG. |
| ReproSil Chiral-D-PhenylGlycin, 5 µm | r15.DPG. |