ReproSil Chiral-GM is a silica-based HPLC stationary phase coated with tris-(4-methylphenyl)carbamate cellulose, specifically developed for enantioselective separations under normal-phase conditions. The cellulose tris-(4-methylphenyl)carbamate chiral selector enables multiple molecular interaction mechanisms – including hydrogen bonding, π–π stacking, and dipole–dipole interactions – providing strong chiral recognition and excellent resolution for a wide range of racemic compounds.
The carefully optimized coating process ensures a uniform and stable chiral layer on high-purity spherical silica, resulting in outstanding mechanical stability, reproducible retention behavior, and consistent enantioselectivity. The unique substitution pattern of the 4-methylphenylcarbamate groups imparts a distinct selectivity profile that complements other cellulose- and amylose-based chiral stationary phases, making ReproSil Chiral-GM particularly valuable for method development and screening in chiral HPLC.
This phase is ideally suited for pharmaceutical, chemical, and biochemical laboratories, offering reliable performance for both analytical and preparative enantioseparations in non-aqueous mobile phase systems such as n-hexane/alcohol mixtures.
ReproSil Chiral-GM combines cellulose-based chiral recognition with the selectivity of tris-(4-methylphenyl)carbamate functionality – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.
For the use of our ReproSil Chiral-GM columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(4-methylphenyl)carbamate cellulose
Designed for enantioselective separations under normal-phase conditions
Excellent chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions
Distinct selectivity profile complementary to other ReproSil Chiral phases
High mechanical stability and reproducibility under routine operation
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of chiral pharmaceuticals and intermediates
Analysis of racemic fine chemicals and natural products
Method development and screening in chiral normal-phase HPLC
Quality control and purity testing of optically active compounds
| Particle Size |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(4-methylphenyl)carbamat-Cellulose |
| Particle Type | |
| Separation Mode | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-GM, 5 µm | r65.gm. |