ReproSil Chiral-JM is a silica-based HPLC stationary phase coated with tris-(4-methylbenzoyl)carbamate cellulose, developed for enantioselective separations under normal-phase conditions. The chiral selector, a cellulose derivative substituted with 4-methylbenzoyl carbamate groups, provides a well-balanced combination of hydrogen bonding, π–π interactions, and dipole–dipole forces, enabling strong chiral recognition and high resolution for a wide variety of racemic analytes.
The coating process ensures a uniform, stable chiral layer on high-purity spherical silica, giving the phase excellent mechanical stability, reproducible retention characteristics, and long operational lifetime. The specific substitution pattern of the 4-methylbenzoyl groups creates a distinct selectivity profile, offering complementary performance to other cellulose- and amylose-based chiral stationary phases. This makes ReproSil Chiral-JM an excellent choice for method development, screening, and routine enantioseparations. Designed for use with standard non-aqueous mobile phases (such as n-hexane/alcohol mixtures), this phase delivers consistent chiral recognition and excellent peak symmetry across a broad range of compound classes including pharmaceuticals, agrochemicals, and fine chemicals.
ReproSil Chiral-JM combines the proven performance of cellulose-based chiral recognition with the distinct selectivity of tris-(4-methylbenzoyl)carbamate functionality – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.
Attractive alternative to CHIRALCEL® OJ-H (Daicel®) and Lux Cellulose-3 (Phenomenex™).
For the use of our ReproSil Chiral-JM columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(4-methylbenzoyl)carbamate cellulose
Designed for enantioselective separations in normal-phase chromatography
Strong chiral recognition through hydrogen bonding, π–π, and dipole–dipole interactions
Unique selectivity profile complementary to other ReproSil Chiral cellulose derivatives
High mechanical stability, reproducibility, and column lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of chiral pharmaceuticals and intermediates
Analysis of racemic fine chemicals and natural products
Method development and screening in chiral normal-phase HPLC
Quality control and stereochemical purity testing in pharmaceutical and chemical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(4-methylbenzoyl)carbamate-Cellulose |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-JM, 3 µm | r63.jm. |
| ReproSil Chiral-JM, 5 µm | r65.jm. |
| ReproSil Chiral-JM, 10 µm | r60.jm. |