ReproSil Chiral-L-PhenylGlycin is a silica-based HPLC stationary phase of the brush-type Pirkle design, modified with N-(3,5-dinitrobenzoyl)-L-phenylglycine as the chiral selector. This phase is specifically developed for the enantioselective separation of herbicides, pharmaceuticals, and aromatic chiral compounds. Its distinct molecular architecture enables selective chiral recognition through donor–acceptor interactions, hydrogen bonding, π–π stacking, and steric complementarity.
The L-phenylglycine moiety provides a defined chiral center, while the electron-withdrawing 3,5-dinitrobenzoyl group functions as a strong π-acceptor site. This combination allows highly selective discrimination of analytes containing aromatic or heteroaromatic systems and electron-donating substituents. As a result, ReproSil Chiral-L-PhenylGlycin delivers excellent resolution for compounds such as phenoxyacetic acid herbicides, pharmaceutical intermediates, and aromatic chiral molecules. The chiral selector is covalently bonded to high-purity spherical silica, ensuring excellent mechanical stability, solvent compatibility, and reproducible chromatographic performance. The phase can be applied under normal-phase, reversed-phase, or polar-organic conditions, offering flexibility for both analytical and preparative use in pharmaceutical, biochemical, and agrochemical laboratories.
ReproSil Chiral-L-PhenylGlycin combines the strong π-acceptor properties of the N-(3,5-dinitrobenzoyl) group with the chiral recognition capability of L-phenylglycine – the reliable choice for precise, high-resolution, and reproducible enantioselective separations of herbicides, pharmaceuticals, and aromatic chiral compounds.
Attractive Alternative to Nucleosil Chiral-3 (Macherey-Nagel).
Silica-based brush-type chiral stationary phase with N-(3,5-dinitrobenzoyl)-L-phenylglycine
Developed for enantioselective separation of herbicides, pharmaceuticals, and aromatic chiral compounds
Strong chiral recognition via donor–acceptor, hydrogen bonding, and π–π interactions
Covalently bonded chiral selector for high chemical and mechanical stability
Applicable in normal-phase, reversed-phase, and polar-organic chromatographic modes
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of phenoxyacetic acid herbicides and related agrochemicals
Resolution of aromatic and heteroaromatic chiral pharmaceuticals
Method development for chiral compounds with π-electron-rich functional groups
Quality control and stereochemical purity testing in pharmaceutical and chemical research
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | N-(3,5-Dinitrobenzoyl)-L-Phenylglycin |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-L-PhenylGlycin, 5 µm | r15.LPG. |