ReproSil Chiral-MID is a silica-based HPLC stationary phase with immobilized tris-(3-chlorophenyl)carbamate amylose, specifically developed for enantioselective separations under normal-phase conditions. The immobilized amylose derivative substituted with 3-chlorophenyl carbamate groups provides strong and versatile chiral recognition through hydrogen bonding, π–π stacking, dipole–dipole interactions, and steric complementarity, enabling high-resolution separations of a broad range of racemic compounds.
The chlorine substituent on the aromatic ring introduces a subtle electronic effect that fine-tunes the polarity and π-acceptor properties of the chiral selector, resulting in distinct and complementary selectivity for various compound classes. The covalent immobilization of the chiral selector ensures exceptional chemical and mechanical stability, allowing the use of a wide variety of mobile phases — including polar and mixed solvent systems — without loss of chiral performance. The stationary phase is built on high-purity spherical silica, providing excellent efficiency, reproducibility, and long column lifetime. ReproSil Chiral-MID is ideally suited for pharmaceutical, chemical, and biochemical applications, particularly for analytical and preparative enantioseparations where high robustness and solvent flexibility are essential.
ReproSil Chiral-MID combines the proven chiral selectivity of amylose tris-(3-chlorophenyl)carbamate with the enhanced stability of an immobilized silica support – the reliable choice for accurate, high-resolution, and reproducible enantioselective separations in normal-phase chromatography.
Attractive alternative to CHIRALPAK® ID (Daicel®).
For the use of our ReproSil Chiral-MID columns, please refer to our Column Care Guide.
Silica-based stationary phase with immobilized tris-(3-chlorophenyl)carbamate amylose
Designed for enantioselective separations under normal-phase conditions
Strong chiral recognition via hydrogen bonding, π–π stacking, and dipole–dipole interactions
Distinct selectivity influenced by chlorine substituents on the aromatic rings
Exceptional chemical stability and extended solvent compatibility
High mechanical strength and long operational lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of pharmaceuticals, fine chemicals, and intermediates
Resolution of racemic mixtures containing aromatic or halogenated structures
Method development in normal-phase and polar-organic chiral HPLC
Stereochemical purity testing and quality control in pharmaceutical and chemical research
| Particle Size |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(3-chlorophenyl)carbamat-Amylose |
| Particle Type | |
| Separation Mode | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-MID, 5 µm | r65.mid. |