ReproSil Chiral-OH is a silica-based HPLC stationary phase specifically developed for the enantioselective separation of aromatic alcohols and aryl carbinols, particularly those with hydroxyl groups located near the chiral center. Designed for operation in the normal-phase mode, this phase offers precise and reliable resolution through a combination of hydrogen bonding, π–π interactions, dipole–dipole forces, and steric recognition.
The chiral selector is covalently bound to high-purity spherical silica, creating a stable and well-defined chiral environment that promotes selective interactions with analytes containing aromatic and hydroxyl functionalities. The presence of the hydroxyl group near the stereogenic center allows the formation of directional hydrogen bonds, resulting in strong chiral recognition and sharp peak shapes. ReproSil Chiral-OH exhibits high efficiency, excellent reproducibility, and long column lifetime, even under routine analytical use. It is particularly suited for pharmaceutical, agrochemical, and fine chemical applications, where the enantioselective resolution of aromatic alcohols, benzylic alcohols, and related structures is essential for purity testing and process control.
ReproSil Chiral-OH provides targeted selectivity for aromatic alcohols and aryl carbinols, combining strong chiral recognition with the robustness of high-purity silica – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.
Silica-based stationary phase designed for aromatic alcohols and aryl carbinols
Optimized for enantioselective separations under normal-phase conditions
Strong chiral recognition through hydrogen bonding, π–π, and dipole–dipole interactions
Stable covalent bonding for excellent mechanical and chemical robustness
High column efficiency, reproducibility, and long operational lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of aromatic and benzylic alcohols
Resolution of aryl carbinols and other compounds with OH groups near the chiral center
Method development for chiral normal-phase separations
Stereochemical purity testing and quality control in pharmaceutical and chemical laboratories
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 300 m²/g |
| Particle Type | |
| Separation Mode | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-OH, 8 µm | r18.oh. |