ReproSil Chiral-OM is a silica-based HPLC stationary phase coated with tris-(3,5-dimethylphenyl)carbamate cellulose, developed for enantioselective separations under normal-phase conditions. The cellulose tris-(3,5-dimethylphenyl)carbamate chiral selector is one of the most established and versatile chiral recognition systems, providing high enantioselectivity for a broad range of racemic compounds.
Chiral recognition is achieved through multiple, synergistic interaction mechanisms — including hydrogen bonding, π–π interactions, dipole–dipole interactions, and steric complementarity — which enable precise resolution of structurally diverse analytes. The coating on high-purity spherical silica ensures excellent mechanical stability, reproducible retention, and long column lifetime, even under routine analytical conditions. ReproSil Chiral-OM offers a robust and universal chiral stationary phase that is highly effective for pharmaceutical, chemical, and biochemical applications, especially for method development and screening of racemic mixtures. It is compatible with standard non-aqueous mobile phases such as n-hexane/alcohol mixtures and delivers sharp, well-resolved peaks with high reproducibility.
ReproSil Chiral-OM combines the proven selectivity of tris-(3,5-dimethylphenyl)carbamate cellulose with the robustness of high-purity silica – the reliable choice for precise and reproducible enantioselective separations in normal-phase chromatography.
Attractive alternative to CHIRALCEL® OD-H (Daicel®) and Lux Cellulose-1 (Phenomenex™).
For the use of our ReproSil Chiral-OM columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(3,5-dimethylphenyl)carbamate cellulose
Designed for enantioselective separations under normal-phase conditions
Strong and broad chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions
High mechanical and chemical stability for routine and method development use
Excellent reproducibility and column lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of pharmaceuticals, fine chemicals, and intermediates
Method development and screening in chiral HPLC
Analysis of racemic natural products and synthetic compounds
Quality control and stereochemical purity determination in pharmaceutical and chemical industries
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(3,5-dimethylphenyl)carbamat-Cellulose |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-OM, 3 µm | r63.om. |
| ReproSil Chiral-OM, 5 µm | r65.om. |
| ReproSil Chiral-OM, 10 µm | r60.om. |
| ReproSil Chiral-OM, 20 µm | r620.om. |