ReproSil Chiral-OM-R is a silica-based HPLC stationary phase coated with tris-(3,5-dimethylphenyl)carbamate cellulose, specifically developed for enantioselective separations under reversed-phase conditions. The cellulose derivative with 3,5-dimethylphenylcarbamate substituents provides a robust and highly versatile chiral recognition system capable of resolving a wide variety of racemic compounds through hydrogen bonding, π–π interactions, dipole–dipole forces, and steric complementarity.
Unlike its normal-phase counterpart, ReproSil Chiral-OM-R is optimized for aqueous and polar mobile phases, offering high stability, reproducibility, and strong enantioselectivity in reversed-phase and polar-organic chromatographic modes. The high-purity spherical silica ensures excellent mechanical stability, consistent retention behavior, and long column lifetime even under gradient conditions and extended use. This phase is particularly well suited for the enantioselective analysis of polar and water-soluble chiral compounds, including pharmaceuticals, metabolites, and biochemical intermediates. Its balanced hydrophobic and polar interactions make it a powerful tool for method development in biopharmaceutical and chemical laboratories.
ReproSil Chiral-OM-R combines the robust chiral recognition of tris-(3,5-dimethylphenyl)carbamate cellulose with reversed-phase compatibility – the reliable choice for accurate and reproducible enantioselective separations in aqueous and polar chromatographic systems.
Attractive alternative to CHIRALCEL® OD-RH (Daicel®).
For the use of our ReproSil Chiral-OM-R columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(3,5-dimethylphenyl)carbamate cellulose
Optimized for enantioselective separations under reversed-phase and polar-organic conditions
Strong chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions
Stable and reproducible in aqueous and mixed solvent systems
High mechanical strength and long operational lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of polar and hydrophilic pharmaceuticals and intermediates
Analysis of chiral biomolecules and metabolites under reversed-phase conditions
Method development for aqueous or mixed solvent chiral HPLC
Quality control and stereochemical purity testing in pharmaceutical and biochemical laboratories
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(3,5-dimethylphenyl)carbamat-Cellulose |
| Particle Type | |
| Separation Modes | |
| USP Code | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-OM-R, 3 µm | r63.omr. |
| ReproSil Chiral-OM-R, 5 µm | r65.omr. |
| ReproSil Chiral-OM-R, 10 µm | r60.omr. |