ReproSil Chiral-PS

Silica-Based Chiral Phase for Aromatic Sulfur- and Phosphorus-Containing Compounds

ReproSil Chiral-PS is a silica-based HPLC stationary phase specifically developed for the enantioselective separation of aromatic compounds containing sulfur or phosphorus atoms, such as sulfoxides, phosphine oxides, phosphonates, thiophosphine oxides, phosphine selenides, and phosphine boranes. The phase provides a chiral environment optimized for compounds with stereogenic heteroatoms, allowing precise and reproducible enantiodiscrimination in the normal-phase mode.

The chiral selector interacts selectively with analytes through π–π stacking, dipole–dipole interactions, hydrogen bonding, and coordination effects, enabling efficient separation of sulfur- and phosphorus-based enantiomers that are often difficult to resolve using conventional chiral phases. The well-defined chiral recognition sites are designed to complement the electronic and steric characteristics of heteroatom-containing aromatic systems, ensuring high selectivity and resolution. ReproSil Chiral-PS is built on high-purity spherical silica, offering excellent mechanical stability, chemical robustness, and long operational lifetime. The phase delivers high efficiency, reproducible retention, and sharp peak shapes, making it ideal for both analytical and preparative chiral HPLC. With its strong selectivity for chiral heteroatom-containing molecules, ReproSil Chiral-PS is particularly suited for applications in pharmaceutical, organometallic, and fine chemical research, as well as for the analysis of stereochemically complex sulfur- and phosphorus-based intermediates.

ReproSil Chiral-PS combines high-purity silica technology with a chiral selector tailored for S- and P-containing molecules – the reliable choice for accurate, high-resolution, and reproducible enantioselective separations of sulfur- and phosphorus-based aromatic compounds in normal-phase chromatography.