ReproSil Chiral-TG is a silica-based HPLC stationary phase with immobilized teicoplanin, a naturally occurring glycopeptide antibiotic known for its exceptional chiral recognition capability. This immobilized glycopeptide phase is designed for broad-spectrum enantioselective separations, offering high selectivity for a wide variety of chiral analytes across multiple compound classes.
The teicoplanin molecule provides a complex chiral environment containing multiple hydrogen bonding sites, aromatic rings, hydrophobic regions, and ionizable functional groups, allowing simultaneous interaction mechanisms such as hydrogen bonding, ionic exchange, π–π stacking, dipole–dipole interactions, and hydrophobic effects. This diversity of binding modes enables the resolution of both neutral and ionic analytes — including amino acids, peptides, β-blockers, acidic and basic drugs, and other biologically active compounds.
The teicoplanin selector is covalently immobilized onto high-purity spherical silica, ensuring excellent chemical and mechanical stability and compatibility with a broad range of mobile phases, including normal-phase, reversed-phase, polar-organic, and aqueous systems. This immobilized design eliminates selector leaching and allows flexible solvent use, providing reliable and reproducible performance even under demanding conditions. ReproSil Chiral-TG is ideally suited for pharmaceutical, biochemical, and clinical research applications, offering robust, high-resolution enantioselective separations for both analytical and preparative use.
ReproSil Chiral-TG combines the broad-spectrum chiral recognition of immobilized teicoplanin with the robustness of high-purity silica – the reliable choice for accurate, flexible, and reproducible enantioselective separations across multiple compound classes and chromatographic modes.
Silica-based stationary phase with covalently immobilized teicoplanin
Broad chiral selectivity for acidic, basic, neutral, and zwitterionic compounds
Multiple recognition mechanisms: hydrogen bonding, ionic, π–π, and hydrophobic interactions
Exceptional stability and solvent compatibility due to covalent immobilization
Operates in normal-phase, reversed-phase, polar-organic, and aqueous modes
High mechanical strength, reproducibility, and long column lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of amino acids, peptides, and β-blockers
Resolution of acidic, basic, and zwitterionic pharmaceuticals
Analysis of chiral drugs, metabolites, and bioactive compounds
Method development and optimization in pharmaceutical and biochemical research
Quality control and stereochemical purity testing in life science and pharmaceutical laboratories
| Particle Size |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 300 m²/g |
| Phase/Modification | Teicoplanin |
| Particle Type | |
| Separation Mode | |
| Endcapping | No |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-TG, 5 µm | r15.tg. |