ReproSil Chiral-ZM-R is a silica-based HPLC stationary phase coated with tris-(3-chloro-4-methylphenyl)carbamate cellulose, specifically developed for enantioselective separations under reversed-phase and polar-organic conditions. The cellulose derivative with 3-chloro-4-methylphenyl carbamate substituents provides a refined balance of electronic and steric properties, resulting in strong and selective chiral recognition through multiple interaction mechanisms such as hydrogen bonding, π–π stacking, dipole–dipole forces, and steric complementarity.
Optimized for aqueous and polar mobile phases, ReproSil Chiral-ZM-R ensures stable retention, excellent resolution, and reproducible results, even under gradient conditions. The presence of both chloro and methyl substituents enhances the polarity balance of the chiral selector, enabling reliable separations of both polar and moderately hydrophobic analytes. Supported by high-purity spherical silica, the phase offers exceptional mechanical stability, long column lifetime, and consistent performance in demanding analytical environments. ReproSil Chiral-ZM-R is particularly suited for pharmaceutical, biochemical, and life-science laboratories, where robust and reproducible enantioselective separations in aqueous chromatographic systems are essential.
ReproSil Chiral-ZM-R combines the chiral recognition capability of cellulose tris-(3-chloro-4-methylphenyl)carbamate with reversed-phase compatibility – the reliable choice for accurate, stable, and reproducible enantioselective separations in aqueous and polar chromatographic systems.
Attractive alternative to CHIRALCEL® OZ-RH (Daicel®).
For the use of our ReproSil Chiral-ZM-R columns, please refer to our Column Care Guide.
Silica-based stationary phase coated with tris-(3-chloro-4-methylphenyl)carbamate cellulose
Designed for enantioselective separations under reversed-phase and polar-organic conditions
High chiral recognition via hydrogen bonding, π–π, and dipole–dipole interactions
Excellent stability and reproducibility in aqueous and mixed solvent systems
High mechanical strength and long operational lifetime
Suitable for analytical and preparative chiral HPLC applications
Enantioselective separation of polar and hydrophobic pharmaceuticals and intermediates
Analysis of chiral biomolecules, metabolites, and synthetic compounds
Method development and optimization in reversed-phase chiral HPLC
Quality control and stereochemical purity testing in pharmaceutical and biochemical research
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 30 m²/g |
| Phase/Modification | Tris-(3-chloro-4-methylphenyl)carbamat-Cellulose |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| Phase | Material Number |
|---|---|
| ReproSil Chiral-ZM-R, 5 µm | r65.zmr. |
| ReproSil Chiral-ZM-R, 10 µm | r60.zmr. |