ReproSil Gold 300 C4

Wide-Pore C4 Column for Gentle Separation of Large Biomolecules

ReproSil Gold 300 C4 from Dr. Maisch HPLC GmbH is a high-purity silica HPLC column with a 300 Å pore size and a butyl bonded phase. The shorter alkyl chain provides reduced hydrophobic retention, allowing mild elution conditions that help preserve the structure and activity of proteins, enzymes, antibodies, and other sensitive biomolecules. The extra-wide pore design ensures efficient mass transfer and optimal accessibility for high-molecular-weight analytes, while delivering sharp peaks, high resolution, and excellent reproducibility.

ReproSil Gold 300 C4 columns from Dr. Maisch HPLC GmbH deliver gentle, reproducible separations with wide-pore accessibility – the preferred choice for sensitive large biomolecule HPLC applications.

Key Features:

  • Fully porous, ultra-pure silica with 300 Å pore size

  • C4 bonding – USP L26 classification

  • Gentle hydrophobic retention for sensitive biomolecules

  • Optimized for proteins, enzymes, and large peptides

  • Manufactured and QC-tested by Dr. Maisch HPLC GmbH

  • Available in 3 µm, 5 µm, 10 µm, and 15 µm particle sizes

Typical Applications:

  • Protein, enzyme, and antibody separations under mild conditions

  • Biopharmaceutical QC and proteomics research

  • Gradient HPLC for large hydrophobic biomolecules

  • Method development for labile and high-molecular-weight analytes

Specifications

Request Product
Particle Sizes
  • 3 µm
  • 5 µm
  • 10 µm
  • 15 µm
Pore Size 300 Å
Surface Area 100 m²/g
Phase/Modification C4
Particle Type
Separation Mode
USP Code
Endcapping Yes
Carbonload 3 %
pH Range 2 to 9

Material Numbers

Phase Material Number
ReproSil Gold 300 C4, 3 µm r33.4g.
ReproSil Gold 300 C4, 5 µm r35.4g.
ReproSil Gold 300 C4, 10 µm r30.4g.
ReproSil Gold 300 C4, 15 µm r315.4g.
ReproSil Gold 300 C2 ReproSil Gold 300 C8

Any questions?
We are here to help you.

info@dr-maisch.com +49 7073 5035 7

Follow us