ReproSil-Pur 1000 ODS-3 is a silica-based HPLC column with octadecyl bonded chemistry on high-purity 1000 Å silica. The ultra-wide pore size provides excellent accessibility for very large biomolecules such as intact proteins, antibodies, glycoproteins, and nucleic acids, while the C18 bonding ensures strong hydrophobic retention and reliable separations.
Compared to narrower-pore C18 phases, ReproSil-Pur 1000 ODS-3 offers improved mass transfer and resolution for ultra-large analytes, making it a powerful tool for biopharmaceutical and proteomics applications. Robust bonding chemistry ensures reproducibility, sharp peak shapes, and long column lifetimes under gradient and high-temperature conditions.
ReproSil-Pur 1000 ODS-3 combines ultra-wide-pore accessibility with proven C18 chemistry – the reliable choice for laboratories analyzing intact proteins and other large biomolecules by HPLC.
High-purity silica with octadecyl (C18, ODS) bonded chemistry
1000 Å ultra-wide-pore structure for intact proteins and large biomolecules
Strong hydrophobic retention with reproducible peak shapes
Robust bonding chemistry for long operational lifetimes
Available particle sizes: 5 µm, 10 µm
Biopharmaceutical analysis of intact proteins, antibodies, and glycoproteins
Proteomics workflows requiring ultra-wide-pore reversed-phase columns
Separation of nucleic acids, oligonucleotides, and large biomolecular complexes
Method development requiring C18 selectivity for very large analytes
| Particle Sizes |
|
|---|---|
| Pore Size | 1 000 Å |
| Surface Area | 25 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 1.6 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil-Pur 1000 ODS-3, 5 µm | r65.93. |
| ReproSil-Pur 1000 ODS-3, 10 µm | r60.93. |