ReproSil-Pur Basic C8-2 is a silica-based HPLC column with octyl bonded chemistry on high-purity silica, specifically optimized for challenging basic analytes. Compared to standard C8 phases, the Basic C8-2 provides improved bonding technology and surface treatment, resulting in enhanced reproducibility, reduced silanol activity, and superior peak symmetry for amines, alkaloids, and other basic compounds.
The medium hydrophobic retention of the C8 bonding allows faster elution compared to C18 while still delivering strong separation performance. This makes ReproSil-Pur Basic C8-2 an excellent choice for routine pharmaceutical and biochemical analysis, as well as method development.
ReproSil-Pur Basic C8-2 provides optimized C8 retention with superior peak quality for basic analytes – the reliable choice for laboratories requiring robust and reproducible HPLC separations.
High-purity silica with octyl (C8) bonded chemistry
Enhanced surface treatment for optimized performance with basic analytes
Medium hydrophobic retention with shorter run times than C18 phases
Reduced silanol activity for sharp and symmetrical peak shapes
Available particle sizes: 3 µm, 5 µm
Pharmaceutical analysis of basic drugs, alkaloids, and amines
Biochemical separations of polar and moderately hydrophobic metabolites
Food and beverage analysis of nitrogen-containing compounds
Environmental testing of cationic and polar organic pollutants
Method development requiring reproducibility and orthogonal selectivity
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 450 m²/g |
| Phase/Modification | C8 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 12 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| ReproSil-Pur Basic-C8-2, 3 µm | r13.b82. |
| ReproSil-Pur Basic-C8-2, 5 µm | r15.b82. |