ReproSil-XR 300 C18

Wide-Pore C18 Column for Large Biomolecule Reversed-Phase HPLC

ReproSil-XR 300 C18 from Dr. Maisch HPLC GmbH is a high-purity silica-based wide-pore HPLC column with a 300 Å pore size and an octadecyl bonded phase. The wide-pore structure ensures optimal accessibility and efficient mass transfer for high-molecular-weight analytes such as proteins, enzymes, antibodies, and peptides. With its strong hydrophobic retention and excellent peak symmetry, this column delivers high resolution and reproducible separations, making it ideal for analytical and preparative workflows in biopharmaceutical and proteomics applications.

ReproSil-XR 300 C18 columns from Dr. Maisch HPLC GmbH combine wide-pore accessibility with strong hydrophobic selectivity – the ideal choice for high-resolution large biomolecule chromatography.

Key Features:

  • Fully porous, ultra-pure silica with 300 Å pore size

  • C18 bonding – USP L1 classification

  • Strong hydrophobic retention for large biomolecules

  • Excellent resolution, peak symmetry, and reproducibility

  • Manufactured and QC-tested by Dr. Maisch HPLC GmbH

  • Available in 3 µm, 5 µm, and 10 µm particle sizes

Typical Applications:

  • Protein and peptide separations in proteomics and biopharma

  • Biopharmaceutical QC and characterization of therapeutic proteins

  • Gradient HPLC of hydrophobic biomolecules

  • Preparative purification of large analytes

Specifications

Request Product
Particle Sizes
  • 3 µm
  • 5 µm
  • 10 µm
Pore Size 300 Å
Surface Area 100 m²/g
Phase/Modification C18
Particle Type
Separation Mode
USP Code
Endcapping Yes
Carbonload 8 %
pH Range 2 to 8

Material Numbers

Phase Material Number
ReproSil-XR 300 C18, 3 µm rx33.9e.
ReproSil-XR 300 C18, 5 µm rx35.9e.
ReproSil-XR 300 C18, 10 µm rx30.9e.
ReproSil-XR 300 C8 ReproSil-XR 300 SCX

Any questions?
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info@dr-maisch.com +49 7073 5035 7

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