ReproSil-XR 300 C8

Wide-Pore C8 Column for Balanced Large Biomolecule Separations

ReproSil-XR 300 C8 from Dr. Maisch HPLC GmbH is a high-purity silica-based wide-pore HPLC column with a 300 Å pore size and an octyl bonded phase. The medium alkyl chain provides balanced hydrophobic retention, enabling efficient separation of proteins, peptides, and other high-molecular-weight biomolecules while allowing faster elution than C18 phases. The wide-pore design ensures optimal accessibility and efficient mass transfer, making this column ideal for analytical and preparative workflows in proteomics, biopharma, and biomolecule purification.

ReproSil-XR 300 C8 columns from Dr. Maisch HPLC GmbH combine wide-pore accessibility with balanced hydrophobic selectivity – the versatile choice for high-resolution large biomolecule chromatography.

Key Features:

  • Fully porous, ultra-pure silica with 300 Å pore size

  • C8 bonding – USP L7 classification

  • Balanced hydrophobic retention for faster elution than C18

  • Excellent resolution, reproducibility, and peak symmetry

  • Manufactured and QC-tested by Dr. Maisch HPLC GmbH

  • Available in 3 µm, 5 µm, and 10 µm particle sizes

Typical Applications:

  • Protein and peptide separations in proteomics and biopharma

  • Biopharmaceutical QC and characterization of therapeutic proteins

  • Gradient HPLC of hydrophobic biomolecules

  • Preparative purification of large analytes

Specifications

Request Product
Particle Sizes
  • 3 µm
  • 5 µm
  • 10 µm
Pore Size 300 Å
Surface Area 100 m²/g
Phase/Modification C8
Particle Type
Separation Mode
USP Code
Endcapping Yes
Carbonload 5 %
pH Range 2 to 8

Material Numbers

Phase Material Number
ReproSil-XR 300 C8, 3 µm rx33.8e.
ReproSil-XR 300 C8, 5 µm rx35.8e.
ReproSil-XR 300 C8, 10 µm rx30.8e.
ReproSil-XR 300 C4 ReproSil-XR 300 C18

Any questions?
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info@dr-maisch.com +49 7073 5035 7

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