ReproSil 300 C18

Wide-Pore C18 Column for Proteins, Peptides, and Large Biomolecules

ReproSil 300 C18 from Dr. Maisch HPLC GmbH is a fully porous, high-purity silica HPLC column with a 300 Å pore size and an octadecyl bonded phase. The extra-wide pore structure ensures efficient mass transfer and optimal accessibility for large biomolecules such as proteins, enzymes, and peptides, while maintaining strong hydrophobic retention. This column offers high resolution, excellent peak symmetry, and robust reproducibility, making it a preferred choice for bioanalytical and biopharmaceutical applications.

ReproSil 300 C18 columns from Dr. Maisch HPLC GmbH combine wide-pore accessibility with strong hydrophobic selectivity – the reliable choice for large biomolecule chromatography in HPLC.

Key Features:

  • Fully porous, ultra-pure silica with 300 Å pore size

  • C18 bonding – USP L1 classification

  • Optimized for large proteins, peptides, and biomolecules

  • Strong hydrophobic retention with excellent selectivity

  • Manufactured and QC-tested by Dr. Maisch HPLC GmbH

  • Available in 5 µm and 10 µm particle sizes

Typical Applications:

  • Protein and peptide mapping in proteomics

  • Biopharmaceutical quality control and characterization

  • Gradient HPLC of high-molecular-weight biomolecules

  • Method development for large analytes

Specifications

Request Product
Particle Sizes
  • 5 µm
  • 10 µm
Pore Size 300 Å
Surface Area 100 m²/g
Phase/Modification C18
Particle Type
Separation Mode
USP Code
Endcapping Yes
pH Range 2 to 8

Material Numbers

Phase Material Number
ReproSil 300 C18, 5 µm r35.96.
ReproSil 300 C18, 10 µm r30.96.
ReproSil 300 C8 ReproSil 300 DEAE

Any questions?
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info@dr-maisch.com +49 7073 5035 7

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