Reprospher 100 4-EP is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, packed with ultra-pure, fully porous spherical silica (100 Å pore size) bonded with 4-ethylpyridine (4-EP) ligands. The phase combines hydrophobic interactions with a basic surface character, offering enhanced peak shape and retention for basic, polar, and aromatic compounds, particularly those prone to tailing on conventional C18 columns. The 4-ethylpyridine functionality provides a more accessible basic surface compared to alkyl phases, improving analyte interaction control and increasing selectivity for method development.
Reprospher 100 4-EP from Dr. Maisch HPLC GmbH offers distinctive reversed-phase performance with a basic character – ideal for laboratories that require improved peak symmetry and alternative selectivity for polar and basic compounds.
4-Ethylpyridine bonded phase on 100 Å spherical silica
Improved peak shape for basic and ionizable analytes
Enhanced selectivity for polar and aromatic compounds
High-purity, fully porous silica for robust and reproducible performance
Manufactured and quality-controlled by Dr. Maisch HPLC GmbH
Separation of basic pharmaceuticals, amines, and polar drugs
Method development for structurally similar polar analytes
LC-MS-compatible reversed-phase workflows
Selectivity enhancement compared to traditional C18 columns
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | 4-Ethylpyridin |
| Particle Type | |
| Separation Modes | |
| Endcapping | No |
| Carbonload | 8 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 4-EP, 5 µm | rs15.4ep. |
| Reprospher 100 4-EP, 10 µm | rs10.4ep. |