Reprospher 100 C18-DE is a reversed-phase HPLC column from Dr. Maisch HPLC GmbH, based on high-purity, fully porous silica with a 100 Å pore size and bonded with octadecyl groups. The DE (double Endcapping) surface treatment effectively suppresses residual silanol activity, significantly improving peak symmetry and retention stability for basic, polar, and tailing-prone analytes. This phase maintains strong hydrophobic retention while offering enhanced reproducibility, making it a reliable choice for pharmaceutical quality control, method development, and LC-MS-compatible workflows.
Reprospher 100 C18-DE from Dr. Maisch HPLC GmbH provides stable and reproducible reversed-phase performance – optimized for high-efficiency separations of basic and polar analytes with improved peak shape.
Octadecylsilane (C18) bonded phase with deactivated endcapping – USP L1
Fully porous silica with 100 Å pore size
Excellent peak shape for basic and ionizable compounds
Strong hydrophobic retention with reduced silanol interaction
Available from 1.7 µm to 10 µm particle sizes
Basic drug substances, impurities, and degradation products
Method development for tailing-sensitive analytes
LC-MS and UV detection in pharmaceutical analysis
Robust reversed-phase separations under acidic pH conditions
| Particle Sizes |
|
|---|---|
| Pore Size | 100 Å |
| Surface Area | 350 m²/g |
| Phase/Modification | C18 |
| Particle Type | |
| Separation Mode | |
| USP Code | |
| Endcapping | Yes |
| Carbonload | 16 % |
| pH Range | 2 to 8 |
| Phase | Material Number |
|---|---|
| Reprospher 100 C18-DE, 1.7 µm | rs117.9de. |
| Reprospher 100 C18-DE, 1.8 µm | rs118.9de. |
| Reprospher 100 C18-DE, 2 µm | rs12.9de. |
| Reprospher 100 C18-DE, 2.5 µm | rs125.9de. |
| Reprospher 100 C18-DE, 3 µm | rs13.9de. |
| Reprospher 100 C18-DE, 3.5 µm | rs135.9de. |
| Reprospher 100 C18-DE, 4 µm | rs14.9de. |
| Reprospher 100 C18-DE, 5 µm | rs15.9de. |
| Reprospher 100 C18-DE, 7 µm | rs17.9de. |
| Reprospher 100 C18-DE, 10 µm | rs10.9de. |